Jon goes to London to be with Liz and Garfield sneaks with him. Meanwhile a deceased Queen gives everything to her cat Prince XII. Her only heir Lord Dargis becomes jealous and tries to kill Prince. Garfield & Odie sneaks out to the streets of London. Lord Dargis throws Prince in the river and ends up in the sewer of London. SMithee the butler believes he found Prince but it was really Garfield and Jon find Odie with Prince and mistakes him for Garfield. Now the Castle animals must keep Garfield safe and keep him thinking he's royal to save their lives.
Garfield: A Tail of Two Kitties actors and actresses include Billy Connolly, Bob Hoskins, Breckin Meyer, Bryce Lenon, David Kallaway, Ian Abercrombie, Jane Horrocks, Jane Leeves, JB Blanc, Jennifer Love Hewitt, Jim Piddock, Judith Shekoni, Lena Cardwell, Melanie Tolbert, Oliver Muirhead, Rhys Ifans, Richard E. Grant, Roger Rees, Roscoe Lee Browne, Sharon Osbourne, Veronica Alicino, Vinnie Jones。