Homeward Bound II: Lost in San Francisco was released in the year 1996。Homeward Bound II: Lost in San Francisco is also called as Quattro zampe a Sa, Perdidos em São Francisco, På rymmen i San Francisco - Den otroliga vandringen 2, Incroyable voyage à San Francisco, De vuelta a casa 2: Perdidos en San Francisco, A Incrível Jornada II - Perdidos em São Francisco, Úton hazafelé 2. - Kaland San Franciscoban。
Shadow, Sassy and Chance are back! It's been three years since their trek through the woods and over the mountains. Now the family lives in San Fransisco and they're taking a vacation in Canada. Only problem, the pets escape from the airport while being put in the cargo area of the plane. Now their family is in Canada and the pets are all alone in San Fransisco. They meet scruffy bully dogs and a gang of rebel dogs all abandoned and have started their own group. Also looking for them is a "Blood Red Van" driven by bumbling dog catchers. Also Chance meets a girl dog and it's love at first bite.