Prozac Nation was released in the year 2001。Prozac Nation is also called as Nación Prozac, Generation X。

Elizabeth "Lizzie" Wurtzel is a teenager accepted in Harvard with a scholarship in journalism. She has been raised by her divorced mother Mrs. Wurtzel since she was two years old, but she misses her father and feels needy and depressive. When she joins the university, she lives with the roommate Ruby and has her sexual initiation with Noah, and her article for the local column in Crimson newspaper is awarded by Rolling Stone magazine. Lizzie becomes abusive in sex and drugs, and her existential crisis and depression increases and she hurts her friends and her mother that love her, while dating Rafe. Mrs. Wurtzel sends her to an expensive psychiatric treatment with Dr. Sterling, in spite of having difficulties to pay for her medical bills of her therapy sessions. After a long period of treatment under medications, and an attempt of suicide, Lizzie stabilizes and adjusts to the real word.

Prozac Nation actors and actresses include Anne Heche, Bill Marchant, Chiara Zanni, Christina Ricci, Cindy Lentol, Colby Johannson, Ian Tracey, Jessica Lange, Jonathan Rhys Meyers, Lou Reed。