Mare Winningham was born on 16 May 1959 in Phoenix, Arizona, USA. His birth name was Mary Megan Winningham.

Mare Winningham appeared in the movie Dandelion(2004), Georgia(1995), "Grey's Anatomy"(2005), Made in Heaven(1987), Miracle Mile(1988), Nobody's Fool(1986), Shy People(1987), "The Brotherhood of Poland, New Hampshire"(2003), The War(1994), Wyatt Earp(1994)。