Nick Mancuso was born on 29 May 1948 in Mammola, Calabria, Italy. His birth name was Nicodemo Antonio Massimo Mancuso.

Nick Mancuso appeared in the movie Black Christmas(1974), Blame It on the Night(1984), Branded(2007), Death Ship(1980), In the Mix(2005), Lives of the Saints(2004), Nightwing(1979), Past Perfect(1998), Rapid Fire(1992), "Total Recall 2070"(1999), Under Siege(1992), Under Siege 2: Dark Territory(1995)。