O Brother, Where Art Thou? was released in the year 2000。

Loosely based on Homer's 'Odyssey' the movie deals with the grotesque adventures of Everett Ulysses McGill and his companions Delmar and Pete in 1930s Mississipi. Sprung from a chain gang and trying to reach Everetts home to recover the buried loot of a bank heist they are confronted by a series of strange characters. Among them sirens, a cyclops, bankrobber George 'Babyface' Nelson (very annoyed by that nickname), a campaigning Governor, his opponent, a KKK lynch mob, and a blind prophet, who warns the trio that "the treasure you seek shall not be the treasure you find."

O Brother, Where Art Thou? actors and actresses include Charles Durning, Chris Thomas King, George Clooney, Holly Hunter, John Turturro, Mia Tyler, Michael Badalucco, Musetta Vander, Ray McKinnon, Tim Blake Nelson。